The REG statement fits the same model as the preceding PROC TRANSREG step. Here, a REG statement makes the grouped fit plot. ) run proc print dataall (obs5) run You can use PROC SGPLOT to simultaneously display the fit plot and the axis table. A comprehensive statistical analysis of these results was carried out, separating donors by age, gender and metabolic rate measured. data all merge sashelp.iris coef2 Row ifn (n le 30, n - 1. Glutathione conjugation (GST) of 1-chloro-2,4-dinitrobenzene was assessed in a smaller pool of fifty donors the metabolic rate was much faster and measured over six minutes using a different methodology to express rates in μg/mg protein/min (converted to μg/cm 2/min). Although certainly important, this test is usually not sufficient to understanding and interpreting fully the interaction, which would require us to know. Using this standardised assay, the rates of sulphation (SULT) and glucuronidation (UGT) of 7-hydroxycoumarin, methylation (COMT) of dopamine and N-acetylation (NAT) of procainamide were measured in the ng/mg protein/h (converted to ng/cm 2/h) range in eighty-seven individuals. Preincubation of an excess of cofactors at 37 ☌ for fifteen minutes in the S9 before introduction of the testing probe, greatly increased the stability of the enzymes. A box plot of the responses at each level of one classification effect, overlaid with a plot of the. The available graph names are provided in Table 18. For more information about ODS Graphics, see Chapter 23, Statistical Graphics Using ODS. UNDERSTANDING FITPLOT SAS SKINWe developed a protocol to handle and store ex vivo skin samples post-surgery and prepare skin S9 fractions to measure the metabolic activity of Phase II enzymes. To produce the EFFECTPLOT displays, ODS Graphics must be enabled. However, published literature is scarce and usually covers a limited and non-representative number of donors. Understanding skin metabolism is key to improve in vitro to in vivo extrapolations used to inform risk assessments of topically applied products.
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